NF-κB Activators

Oxidative stress
Oxidative stress activates NF-κB, which in turn promotes the expression of genes encoding pro-inflammatory cytokines. [1]


Psychological Stress

The NF-kB signaling pathway is turned on by stress, which in turn reduces the growth of neural stem-like cells. [2]

Overeating – too many carbs, fat or protein will activate NF-κB. [3]


An unhealthy diet

Lack of inhibitory phytochemicals [42].

Minerals

Magnesium [43],

Chromium [44]

Zinc
can inhibit NF-κB. Also, plant-based foods have phytic acid, which inhibits NF-κB [46]

High blood glucose levels [47]

usually because of high glycemic index foods [48]

Low active Vitamin D
(1,25) [49]

Smoking [50]

Lectins like ConA [51] (found in legumes)

Circadian Rhythm Disruption [52]

Sleep deprivation [53]

Sun/UV rays [54]

Acute exercise [55]

Alcohol [56]

Excess fat in the blood [16] (from excess fat, carbs or fat tissue/obesity)

Obesity [16]

Excess saturated fat [57] (but not caprylic acid and lauric acid)

Heavy metals [58]

High protein diet (via IGF-1) [59]

Aldosterone [60]

AngiotensinII [61]

Goji Berries [62]

Reishi [63] – depends on the cells. It also inhibits it.

Lithium [64] (in intestinal cells)

Diseases Linked to Inflammation That display Chronic Activation of NF-B

Aging [7]

Cancer – about 45 cancers [8]

Autoimmune and inflammatory diseases

Multiple Sclerosis [9]
Lupus [10]
Heart Disease
Atherosclerosis [11]
Stroke[12]
Angina [13]
Diabetes [14] – Type 1&2 [15],
Insulin resistance [16]
Obesity [17]
Pain [18]
Anxiety [2]
Depression[4]
Schizophrenia [19]
Bipolar (Anorexia?) [20]
Gut diseases [21]
IBS[22]
Crohn’s [23]
Colitis [23]
Chronic Fatigue Syndrome [24]
Arthritis [25]
Migraines [26, 4]
Headaches [21]
Allergies [27]
Asthma [28]
COPD [29]
Alzheimer’s [30]
Parkinson’s [31]
ALS [32]
Osteoporosis [33]
Sleep apnea [34]
Eczema [35]
Psoriasis [36]
Kidney disease [37]
Sarcopenia [38]
HIV-1 activation [39]
Sepsis [25]
Gastritis [25]