Have you ever heard of phloretin? This natural chalcone, found in apple peels, pears, and grapes, has been making waves in the health world for its potential anti-inflammatory properties.

Studies have found that phloretin can help inhibit the expression of pro-inflammatory molecules like cytokines, as well as activate various anti-inflammatory signaling pathways like PI3K/Akt. [1] This action makes it appealing for use in treating conditions such as acne, photoaging, and neuroinflammation.

But that’s not all – phloretin has also been found to have antioxidant properties that can reduce oxidative stress and lipid peroxidation that are implicated in the pathogenesis of chronic diseases. Moreover, it has anticancer properties that may inhibit cancer cell growth and proliferation.

While more research is necessary, early findings are promising. Given that phloretin is found in multiple common fruits, it can easily fit into your daily diet.

So next time you’re biting into an apple or pear, remember that not only are you enjoying a healthy snack, but you’re also consuming a natural chalcone that could offer numerous health benefits.

Phloretin has been shown to have antioxidant properties that can reduce oxidative stress and lipid peroxidation implicated in the pathogenesis of chronic diseases, as well as anticancer properties that may inhibit cancer cell growth and proliferation. While there is limited research on the potential effects of phloretin specifically for autoimmune disorders, its immunomodulatory effects, anti-inflammatory properties, and antioxidant properties could have potential benefits relevant to such conditions.

Studies have shown that phloretin can help inhibit the expression of nuclear factor-kappa B (NF-kB), a transcription factor involved in inflammation and immune response. [2]  Phloretin may also modulate other inflammatory signaling pathways, like mitogen-activated protein kinases (MAPKs) and IL-6, TNF-α, iNOS and COX-2. [2]

In addition to its anti-inflammatory effects, phloretin may have other health benefits related to disease prevention. For example, it has been shown to have antioxidant properties that can help reduce oxidative stress and lipid peroxidation, which are implicated in the pathogenesis of various chronic diseases like diabetes, cancer, and cardiovascular disease.

Regarding autoimmunity, while there is still limited research on the specific effects of phloretin, some studies suggest it may have immunomodulatory effects that could benefit autoimmune disorders. For example, a study on mice with lupus nephritis found that phloretin treatment reduced inflammation, proteinuria, and glomerular damage, possibly by regulating the immune response. [3]

Overall, while more research is needed to fully understand the effects of phloretin on inflammation and disease prevention, current evidence suggests that it may have potential benefits that could be relevant for those with autoimmune disorders like rheumatoid arthritis.