CD86 is a gene that encodes a type I membrane protein that is a member of the immunoglobulin superfamily [1] . It is expressed by antigen-presenting cells and is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4 [2].
CD86 is constitutively expressed on interdigitating DCs, Langerhans cells, peripheral blood DCs, memory B cells, and germinal center B cells, and macrophages [3].
CD86 is also associated with diseases such as Plague and Cowpox [4].
CD80 and CD86 expressed by antigen-presenting cells have different structural organizations, with CD80 being a bivalent dimer and CD86 being a monomer [5].
1, https://en.wikipedia.org/wiki/CD86
2, https://www.thermofisher.com/antibody/primary/target/cd86
3, https://www.sciencedirect.com/topics/neuroscience/cd86
4, https://www.genecards.org/cgi-bin/carddisp.pl?gene=CD86
5, https://www.cell.com/trends/immunology/fulltext/S1471-4906(03)00111-X