CD80 is a transmembrane glycoprotein that is part of the Ig superfamily and can be found on dendritic cells, activated B-cells, macrophages and T-cells[1]. Its role includes promoting T-cell activation, regulating normal and malignant B-cells[2], as well as serving as an activation marker of Th17 cells[3].
Recent research has shown that targeting the CD80/86 axis could be a promising strategy for dampening excessive inflammation[4]. Furthermore, targeting this pathway could potentially have therapeutic applications in treating several autoimmune disorders, such as multiple sclerosis or rheumatoid arthritis, which involve pro-inflammatory mediators [5].
https://www.sciencedirect.com/topics/immunology-and-microbiology/cd80
https://en.wikipedia.org/wiki/CD80
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC416533/
https://www.nature.com/articles/s41577-020-0306-5
https://www.nature.com/articles/s41598-021-90797-0